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Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions #(2022)

Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions

Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions

  • Title: Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions
  • Author: Richard F. Harris
  • ISBN: 9780465097906
  • Page: 331
  • Format: Hardcover
Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions By Richard F. Harris,




[PDF] Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions | by ✓ Richard F. Harris - Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions, Rigor Mortis How Sloppy Science Creates Worthless Cures Crushes Hope and Wastes Billions American taxpayers spend billion annually funding biomedical research By some estimates half of the results from these studies can t be replicated elsewhere the science is simply wrong Often rese


Recent Comments "Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions"

This is a difficult book to review as many terms that would be used in the review are not easily translated into an elemental language for those who have little knowledge of cell categories and other extremely specific particles and culture lines used in research Quite apart from the animal usually mice or other aspects of the research environment which are not common connotation for those outside of those technical fields and innovative drug research facilities But I ll try.Suffice it to say th [...]

Quick review Many biomedical researchers are already aware of the content of this book, but for academics in other fields, or people who plan to donate money to biomedical research, I highly recommend it Biomedical science is falling sway to the law of diminishing returns These are no longer the days when new cures pop up out of nowhere during quick tests Complex new technologies have opened up millions of new possibilities for discovering agents of disease or possible treatments, while creating [...]

Here we have a strongly effective look at the science and business behind any and all medication It encompasses virtually everything how we ve had no real advancements since the 1980s, how a far too big portion of the scientific journals are based on incorrect information, and how there s a general lack of confirming theories presented in peer reviewed articles Seriously though, the thing that absolutely flabbergasted me was the lack of actual advancement in recent years It s so hard to correlat [...]

I read an advanced print copy to prepare for an interview This book hit a little close to home since I was, until recently, a biomedical research scientist I thought Harris did a great job spelling out all the problems in the field His prose is clean and elegant Biomedical science is hard to write about for a general audience so complicated and I think Harris did a great job My only complaint is that I wish he had gone into making the case for why we should still fund science.

This book made me question a lot of choices people have made within my field But here s to hoping that I don t make those same mistakes I really liked that this book made the issues within the field of biomedical research obvious to the reader I also liked that one didn t need to have a strong background in biochemistry for most of the book Some parts were a little hard to follow, but overall it was an eye opening read.

The author, Richard Harris, provides a terrifying look at the state of scientific literature I read the scientific literature almost daily as part of my job and professional development I am trained to look for flaws in data analyses and reporting Some of the information in the book did not surprise me However, I was nor aware of the extent of the problem Harris provides numerous examples of specific papers that are incorrect and examples of studies that evaluate the widespread problems in scien [...]

It seems like every other week a new study hits the news Red wine cures cancer, coffee is terrible for you, taking vitamins is crucial for good health, red wine might actually cause cancer, caffeine in small amount is good for you, vitamins are worthless With this whirlpool of conflicting information coming rapid fire into the public sphere, one could certainly forgive the average person if they stopped paying attention, or even started to doubt everything they hear from a scientific source.In R [...]

A really important book It is sad and frustrating that there are so many fixable problems with the modern day research world I hope that the reformers offering glimmers of hope throughout this book are able to gain ground and get things back on track, or we may be stuck for a long while.Popsugar challenge 2017 a book with career advice

Despite the sensational title I do appreciate the pun though , this is a calmly researched and explained story of biomedical research Very accessible to non scientists, but I dog eared some references in the primary literature I want to follow up on.One of my favorite people in my lab is the staff scientist who s been in biology for decades It s so enlightening to talk to someone who s been paying attention long enough to connect the dots As a grad student, it s hard for me to know whether the p [...]

Informative and really interesting look at the research science field and the flaws in it Honest look at the incentives for funding, lack of thorough checking of experiments, results, papers, etc Not a boring for being a book about the ins and outs of this field I will say it does perhaps lack bias in its opinion of research science field a bit, which is one of the key points in this book for the flaws in research science, haha

Ulp About the crisis of reproducibility in the medical field, which appears at least as bad as the crisis of reproducibility in behavioral psychology I learned about Eroom s Law, the opposite of Moore s law, which holds that there is an exponential slowing in the state of drug development, starting in 1950 if it holds, we ll be done in 2040 Lack of rigor in biomedical research is an important culprit Even if mice are good models which they often aren t it turns out that cage position can affect [...]

Unconscious bias among scientists arises every step of the way p 15 This reminded me of the 11.10.17 presentation Dr Ryan did about the scientific method, and the fact that there are opportunities for creativity at every step of the process Just as we can ask questions about the ingenuity our scientists exhibited at each step in the process, we can also ask questions about how they employed rigor at each step of the process Failure and ignorance propel science forward p 39 Funding was stretched [...]

Rigor Mortis explores how perverse incentives and a broken scientific culture are fueling the reproducibility crisis in modern biomedical research Published in April, Harris s jeremiad was a perfect fit for my 2017 reading theme on The Integrity of Western Science and an excellent companion to Goldacre s Bad Science.Harris argues that competition for funding, politicized peer review, and pressure to be the first to publish have enabled sloppiness and dubious practices like p hacking to flourish [...]

Very interesting to read this alongside , since the latter touts the rise of science and its hopeful aims to grant humanity immortality and, frankly, divinity Richard F Harris s book reminds us that the problem with science is that scientists are unfortunately human, and just as humans have managed to make messes of religion and government and whatever else we get our hands on, science is not immune Yes, yes, the hope with science is that eventually the truth will out, but meanwhile we re left i [...]

Anyone who has ever talked to me knows that I think academic reasearch is fundamentally broken, and so you d expect that I would love this book And, generally, I thought Harris s points were all very salient and well researched I did at times throughout the book wonder who it was written for it s simple prose suggests the desire to reach a general audience, but its discussion of the scientific process sometimes felt to me like it required familiarity of its readers to the process The two major p [...]

Most of science is built on inference rather than direct observation We can t see the atoms or molecules inside our bodies, and we can t truly explain the root cause of disease Science progresses by testing ideas indirectly, throwing out the ones that seem wrong, and building on those best supported by the facts at hand.I liked learning about the Six Red Flags for Suspect Work written by Glenn Begley because it told of the questions researchers should be asking.rigor Mortis talks about the impor [...]

Disturbing, but interesting and easy to understand The only sciencey story I didn t get was about a company that is making fake organs on clear plastic chips How can that be But the basic premise of the book is that biomedical research has many issues that make a lot of experiments unlikely to be reproducible He includes quite a few examples of experiments and clinical trials that have gone wrong and why Unfortunately, the problems frequently aren t identified until long after the paper has been [...]

Generally I don t care for popular science books by popular science writers, but this one is interesting because it s a book about meta research, it has somewhat rigor than your standard, gushing science as narrative story As someone already very familiar with the concepts herein, I didn t see anything obviously objectionable with Harris portrayal of the story so far.That said, it is popular science, so it probably is oversimplified in various horrible ways I think that the story of medicine, p [...]

This is a very interesting but almost scary book Billions of dollars are spent year to finance studies, test trials, and drugs to aide in curing or alleviating the ravages of illness Many arrive at the wrong conclusions This book opens some of the ways that happens and some of the methods some scientists use their research to enhance their own careers and reputations To be fair, it also points out ways that can combat this Occasionally, that happens but not always That does not erase the good th [...]

Harris ultimately tackles the same issue and says the same thing in 10 different ways scientists are sloppy because they re either pushed to hard to publish, not being careful, or just don t care While its a important and rarely talked about point as he mentions multiple times that bad experimental design and execution leads to bad data which leads to all kinds of waste money, time, hope I feel this would have been better accomplished in a series of articles and overall the book was just a littl [...]

I didn t finish every bit of this one it was a bit on the technical side for me but its contents and premise were dismaying about just how much medical research is contaminated, misrepresented and useless Huge amounts of time, effort, and funding are wasted.A major example was HeLa cells from the famous Henrietta Lachs which have permeated a huge portion of cells which experimenters believe are other types of cells and hence draw dubious conclusions from Other examples are experiments which even [...]

This book needs to be read by every knucklehead that thinks the Global warming debates are over To fully understand this book you will need a working knowledge of the scientific method Heartbreaking at points, but does leave a little optimism and does show some possible solutions If you like this book read Dr Ben Goldacre s for information.

Must read for anyone doing, reviewing or funding biomedical researchThis book has quickly become one of my favorites of all times Points out the perverse incentives of academic research, fueled by many other sectors Best of all, they offer simple solutions albeit challenging to inact As with most things in life, the you police yourself, the less others will need to do it for you Let s hope this sector takes it to heart.

Interesting book, but left me feeling rather depressed I suppose that cell lines can be verified, and lab mice carefully chosen, but the nature of tenure is unlikely to change If scientists have to crank out publications for tenure, that s what they ll do.

A must read for all scientists Neatly outlays the problems with reproducibility in biomedical research, and offers insight in ways to change the academic and institutional culture that promotes publishing quantity over quality.

We tend to hold research science on a pedestal This book removes the pedestal and digs a deep hole that research needs to climb out of And while it focuses on biomedical research, I have a feeling that it speaks to much of the scientific research community.

I gave this a 4 because I am really interested in the topic and the author did a good job for scientists and I think non scientists of laying out the problem It s not anyone s fault, but the system needs overhaul.

interesting, but scientific than I anticipated.

Well written, engaging and dispassionate love it particularly from my perspective as a scientist researcher

How easy is is for scientific research to get it wrong, why this matters, and what is now being done about it.


  • [PDF] Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions | by ✓ Richard F. Harris
    331 Richard F. Harris
Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions